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The American West: Virtual Library
An interesting gateway site with links organized by topic, geographic region, and chronology. There are also links, photos, bibliographies, a wide variety of primary documents and a useful introduction to "doing research."
Discovering Lewis & Clark
The Lewis and Clark Fort Mandan Foundation has created this website which includes comprehensive coverage of the expedition and journal entries.
The First American West: The Ohio River Valley 1750 - 1820
Part of the American Memory Project of the Library of Congress, this site has more than 15,000 pages of historical materials including newspapers, pamphlets, letters, journals, books, maps and more. Specific links of interest include Aaron Burr, James Wilkinson, Native Americans and documents relating to traveling the region.
Spain, The United States, and The American Frontier: Historias Paralelas
Created by the Library of Congress in collaboration with The National Library of Spain, and The Biblioteca Columbina y Capitular of Seville, this collection of primary and secondary historical documents explore the "history of Spanish expansion into North America from Florida, Georgia, the Carolinas, and across most of what is now the modern-day American Southwest all the way north to Alaska."
Trails of Hope
A collection of the original writings of 49 voyagers on the Mormon, California, Oregon, and Montana trails who wrote while traveling on the trail. Also includes photographs and maps.